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Search results (52)

« Back to Publications

Covalently constrained 'Di-Gembodies' enable parallel structure solutions by cryo-EM.

Yi G. et al, (2026), Nat Chem Biol, 22, 69 - 76

Crystal structure of fatty acid thioesterase A bound by 129 fragments provides diverse development opportunities.

Kot E. et al, (2026), Pest Manag Sci, 82, 151 - 168

High-throughput crystallographic fragment screening of Zika virus NS3 Helicase.

Godoy AS. et al, (2025)

Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors.

Ni X. et al, (2025)

Heterologous production, purification and crystallization of 24C-sterol methyltransferase from Candida albicans

Mpontshane NS. et al, (2025)

Accelerating Drug Discovery With High-Throughput Crystallographic Fragment Screening and Structural Enablement

Fearon D. et al, (2025), Applied Research, 4

Crystal structure of Fatty Acid Thioesterase A bound by 129 fragments provides diverse development opportunities

Kot E. et al, (2024)

Identifying novel chemical matter against the Chikungunya virus nsP3 macrodomain through crystallographic fragment screening.

Aschenbrenner JC. et al, (2024)

Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response.

Lee AA. et al, (2024)

Di-Gluebodies as covalently-rigidified, modular protein assemblies enable simultaneous determination of high-resolution, low-size, cryo-EM structures

Yi G. et al, (2024)

Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals.

Lithgo RM. et al, (2024)

A selection of Golden Gate vectors to simplify recombinant protein production in Escherichia coli

Fairhead M. et al, (2024)

Crystallographic fragment screen of Enterovirus D68 3C protease and iterative design of lead-like compounds using structure-guided expansions

Lithgo R. et al, (2024)

Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.

Boby ML. et al, (2023), Science, 382

Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease.

Godoy AS. et al, (2023), Nucleic Acids Res, 51, 5255 - 5270

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