Osipov EM., Munawar AH., Beelen S., Fearon D., Douangamath A., Wild C., Weeks SD., Van Aerschot A., von Delft F., Strelkov SV.

Crystallographic screening with drug-like fragments was performed on main capsid protein VP1 of BK polyomavirus. 144 binding fragments clustering to six pockets were established, opening up a perspective of designing capsid assembly inhibitors.

Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors

Osipov EM., Munawar AH., Beelen S., Fearon D., Douangamath A., Wild C., Weeks SD., Van Aerschot A., von Delft F., Strelkov SV.

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