"Design principles of a membrane-spanning ubiquitin ligase".

Williams C., Nocka LM., Hedger G., Parashara P., Pardon E., Latorraca NR., Pusapati GV., Lartey D., Gao L., Milenkovic L., Chalk R., Steyaert J., Marqusee S., Carrique L., Bazan JF., Rouse SL., Kong JH., Siebold C., Rohatgi R.

DOI

10.1101/2025.09.11.675358

Type

Preprint

Publication Date

2025-09-16T00:00:00+00:00

Keywords

Carpenter syndrome, E3 ligase, birth defects, cryo-EM structure, molecular dynamics simulations, morphogens, signaling, transmembrane receptor, ubiquitylation

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