Medicinal Chemistry Research Associate
Tamas Szommer earned his MSc in Medicinal Chemistry at the Budapest University of Technology and Economics (under the supervision of Prof. Gyorgy Kalaus) in 2003. He started his industrial career at ComGenex Inc. in Hungary as medicinal chemist and he led numerous custom library and combinatorial library synthesis projects. He also actively participated in the development and introduction of ComGenex’s proprietary central ELN database system. In the meantime he was actively involved into the development of a database for structural evolution (EMIL - `Example-Mediated Innovation for Lead-Evolution` leading by Prof. Toshio Fujita, CompuDrug Inc.). In 2006 ComGenex was acquired by Albany Molecular Research Inc. and Tamas was promoted to Head of Microwave and Parallel Chemistry and he was responsible for the operation and continuous development of the Parallel Chemistry Group in Hungary. He participated in the design and synthesis of small molecular libraries, custom library projects, fragment-based drug discovery projects and numerous natural product-like libraries. In 2012 Tamas successfully managed a technology transfer project at AMRI Hyderabad in India then he joined to ComInnex Inc. (Hungary) for a couple of months to `set up` a medicinal chemistry laboratory.
Tamas joined Prof. Paul Brennan’s Group at the Target Discovery Institute in 2013 to participate in the development of epigenetic chemical probes.
Novel Starting Points for Human Glycolate Oxidase Inhibitors, Revealed by Crystallography-Based Fragment Screening.
Mackinnon SR. et al, (2022), Front Chem, 10
Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death.
Cottone L. et al, (2020), Cancer Res, 80, 4540 - 4551
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.
Resnick E. et al, (2019), J Am Chem Soc, 141, 8951 - 8968
Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7.
Gerken PA. et al, (2017), Angew Chem Int Ed Engl, 56, 15555 - 15559
Parallel synthesis of 1,2,4-triazole derivatives using microwave and continuous-flow techniques.
Szommer T. et al, (2012), Mol Divers, 16, 81 - 90