Matteo Ferla
My interest lies with the structural side of protein: how do they function and what effects are mutations having on them?
My role within the group is to try to understand what are the structural effects of various mutations found by the HICF2 WGS sequencing programme and to interface with the Structural Genomics Consortium. This is a fascinating work as every protein has a different story to tell, each with their own secrets and challenges. In fact, only couple of cases have a straightforward delta-Gibbs change that unravels them, instead the effect range from catalytic or interface to altered sorting motifs.
Personal site: www.matteoferla.com
Github: github.com/matteoferla
Blog: blog.matteoferla.com/
Twitter: https://twitter.com/matteoferla
Recent publications
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Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Journal article
Boby ML. et al, (2023), Science, 382
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Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases.
Journal article
Pagnamenta AT. et al, (2023), Genome Med, 15
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Biallelic MED27 variants lead to variable ponto-cerebello-lental degeneration with movement disorders.
Journal article
Maroofian R. et al, (2023), Brain
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The prevalence and phenotypic range associated with biallelic PKDCC variants.
Journal article
Pagnamenta AT. et al, (2023), Clin Genet
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Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2.
Journal article
Gahbauer S. et al, (2023), Proc Natl Acad Sci U S A, 120