Daniel Ebner
Associate Professor/PI and Member of congreation
Daniel Ebner is an Associate Professor and Principal Investigator at the University of Oxford and heads the TDI High Throughput Cellular Screening Facility and the Oxford CRISPR/Cas9 Screening Facility at the Target Discovery Institute (TDI), Centre for Medicines Discovery, Nuffield Department of Medicine. Daniel’s main academic research, through a five year £7M CRUK funded grant in collaboration with researchers from the University of Edinburgh and MIT, is focused on identifying and advancing novel combinatorial therapeutics for the treatment of glioblastoma. As head of the cellular screening facility, Daniel has worked with academic and industrial collaborators to complete >150 research projects and has published >70 peer-reviewed papers in the past 5 years in high impact journals such as the Lancet, New England Journal of Medicine, Nature and Journal of the American Medical Association across a broad range of pathologies including on neurodegeneration, inflammation, autophagy, large-scale iPSC CRISPR/Cas9 screening methods, and novel more physiologically relevant screening models. Previous to his academic career at the University of Oxford, Daniel has worked for >10 years in the biotechnology and pharmaceutical industry.
Recent publications
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Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models
Journal article
Rodriguez-Berriguete G. et al, (2023), Clinical Cancer Research
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Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region.
Journal article
Emmenegger M. et al, (2023), iScience
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A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk.
Journal article
Rottner AK. et al, (2022), Nat Genet
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Minimalised Three-Dimensional Human Midbrain In Vitro Model for Neurotoxicity Evaluation of DYRK1 Inhibitors
Preprint
Wan X. et al, (2022)
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Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models
Preprint
Rodriguez-Berriguete G. et al, (2022)