{ "items": [ "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL).\n

\n \n \n

\n \n Journal article\n \n

\n \n\n \n \n \n

Heidenreich D. et al, (2018), J Med Chem, 61, 10929 - 10934

\n \n \n \n

\n

\n

\n \n \n
\n\n
\n\n
\n\n\n", "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n Discovery of an MLLT1/3 YEATS Domain Chemical Probe.\n

\n \n \n

\n \n Journal article\n \n

\n \n\n \n \n \n

Moustakim M. et al, (2018), Angew Chem Int Ed Engl, 57, 16302 - 16307

\n \n \n \n

\n

\n

\n \n \n
\n\n
\n\n
\n\n\n", "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n An Activity-based Probe Targeting Non-catalytic, Highly Conserved Amino Acid Residues Within Bromodomains\n

\n \n \n

\n \n Journal article\n \n

\n \n\n \n \n \n

D\u2019Ascenzio M. et al, (2018)

\n \n \n \n

\n

\n

\n \n \n
\n\n
\n\n
\n\n\n", "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n Rapid covalent-probe discovery by electrophile fragment screening\n

\n \n \n

\n \n Preprint\n \n

\n \n\n \n \n \n

Resnick E. et al, (2018)

\n \n \n \n

\n

\n

\n \n \n
\n\n
\n\n
\n\n\n", "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n Epigenetic inactivation of oncogenic brachyury (TBXT) by H3K27 histone demethylase controls chordoma cell survival\n

\n \n \n

\n \n Preprint\n \n

\n \n\n \n \n \n

Cottone L. et al, (2018)

\n \n \n \n

\n

\n

\n \n \n
\n\n
\n\n
\n\n\n", "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n Design, Synthesis and Characterization of Covalent KDM5 Inhibitors\n

\n \n \n

\n \n Working paper\n \n

\n \n\n \n \n \n

Vazquez-Rodriguez S. et al, (2018)

\n \n \n \n

\n

\n

\n \n \n
\n\n
\n\n
\n\n\n", "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n Bench-Stable Transfer Reagent Facilitates the Generation of Trifluoromethyl-sulfonimidamides.\n

\n \n \n

\n \n Journal article\n \n

\n \n\n \n \n \n

Wright M. et al, (2018), J Org Chem, 83, 9510 - 9516

\n \n \n \n

\n

\n

\n \n \n
\n\n
\n\n
\n\n\n", "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2.\n

\n \n \n

\n \n Journal article\n \n

\n \n\n \n \n \n

Moustakim M. et al, (2018), Bioorg Med Chem, 26, 2965 - 2972

\n \n \n \n

\n

\n

\n \n \n
\n\n
\n\n
\n\n\n", "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n Halogen-Aromatic \u03c0\u2005Interactions Modulate Inhibitor Residence Times.\n

\n \n \n

\n \n Journal article\n \n

\n \n\n \n \n \n

Heroven C. et al, (2018), Angew Chem Int Ed Engl, 57, 7220 - 7224

\n \n \n \n

\n

\n

\n \n \n
\n\n
\n\n
\n\n\n", "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n Identifying Small-Molecule Binding Sites for Epigenetic Proteins at Domain-Domain Interfaces.\n

\n \n \n

\n \n Journal article\n \n

\n \n\n \n \n \n

Bowkett D. et al, (2018), ChemMedChem, 13, 1051 - 1057

\n \n \n \n

\n

\n

\n \n \n
\n\n
\n\n
\n\n\n", "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n Mild, calcium catalysed Beckmann rearrangements.\n

\n \n \n

\n \n Journal article\n \n

\n \n\n \n \n \n

Kiely-Collins HJ. et al, (2018), Chem Commun (Camb), 54, 654 - 657

\n \n \n \n

\n

\n

\n \n \n
\n\n
\n\n
\n\n\n", "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n Development of 8-pyridopyrimidinone-based covalent inhibitors of KDM5B\n

\n \n \n

\n \n Conference paper\n \n

\n \n\n \n \n \n

Wright M. et al, (2018), ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 256

\n \n \n \n

\n \n

\n \n \n
\n\n
\n\n
\n\n\n", "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n Development of a YEATS-domain chemical probe\n

\n \n \n

\n \n Conference paper\n \n

\n \n\n \n \n \n

Moustakim M. et al, (2018), ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 256

\n \n \n \n

\n \n

\n \n \n
\n\n
\n\n
\n\n\n", "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n Development of KDM5 covalent inhibitors as chemical probes\n

\n \n \n

\n \n Conference paper\n \n

\n \n\n \n \n \n

Vazquez-Rodriguez S. et al, (2018), ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 256

\n \n \n \n

\n \n

\n \n \n
\n\n
\n\n
\n\n\n", "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n Principles and Applications of Fragment-based Drug Discovery for Chemical Probes\n

\n \n \n

\n \n Chapter\n \n

\n \n\n \n \n \n

Moustakim M. and Brennan PE., (2018), CHEMICAL AND BIOLOGICAL SYNTHESIS: ENABLING APPROACHES FOR UNDERSTANDING BIOLOGY, 10, 114 - 137

\n \n \n \n

\n \n

\n \n \n
\n\n
\n\n
\n\n\n", "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n Target Identification Using Chemical Probes.\n

\n \n \n

\n \n Chapter\n \n

\n \n\n \n \n \n

Moustakim M. et al, (2018), 610, 27 - 58

\n \n \n \n

\n

\n

\n \n \n
\n\n
\n\n
\n\n\n", "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7.\n

\n \n \n

\n \n Journal article\n \n

\n \n\n \n \n \n

Gerken PA. et al, (2017), Angew Chem Int Ed Engl, 56, 15555 - 15559

\n \n \n \n

\n

\n

\n \n \n
\n\n
\n\n
\n\n\n", "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n Discovery of a Highly Selective Cell\u2010Active Inhibitor of the Histone Lysine Demethylases KDM2/7\n

\n \n \n

\n \n Journal article\n \n

\n \n\n \n \n \n

Gerken PA. et al, (2017), Angewandte Chemie, 129, 15761 - 15765

\n \n \n \n

\n

\n

\n \n \n
\n\n
\n\n
\n\n\n", "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery.\n

\n \n \n

\n \n Journal article\n \n

\n \n\n \n \n \n

Bradley AR. et al, (2017), Essays Biochem, 61, 495 - 503

\n \n \n \n

\n

\n

\n \n \n
\n\n
\n\n
\n\n\n", "\n\n
\n\n
\n\n \n\n
\n \n \n
\n \n
\n \n \n

\n Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation.\n

\n \n \n

\n \n Journal article\n \n

\n \n\n \n \n \n

Meier JC. et al, (2017), ACS Chem Biol, 12, 2619 - 2630

\n \n \n \n

\n

\n

\n \n \n
\n\n
\n\n
\n\n\n" ], "more": "\n\n \n \n Load More\n \n \n\n", "msg": "" }