Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution
Preprint
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Data from GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner
Other
Wang Z. et al, (2024)
Molecular insights into the stimulation of SNM1A nuclease activity by CSB during interstrand crosslink processing
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Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L.
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Zhu K. et al, (2024), EMBO Rep
USP24 is an ISG15 cross-reactive deubiquitinase that mediates IFN-I production by de-ISGylating the RNA helicase MOV10
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Mukhopadhyay R. et al, (2024)
Multi-omics analysis of virus-permissive versus hostile cellular states reveals protein networks controlling virus infection
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Identifying novel chemical matter against the Chikungunya virus nsP3 macrodomain through crystallographic fragment screening.
Preprint
Aschenbrenner JC. et al, (2024)
Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response.
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A BTB extension and ion-binding domain contribute to the pentameric structure and TFAP2A binding of KCTD1.
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Luminescence-based complementation assay to assess target engagement and cell permeability of glycolate oxidase (HAO1) inhibitors.
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Mackinnon SR. et al, (2024), Biochimie
Cyclin F-EXO1 axis controls cell cycle-dependent execution of double-strand break repair.
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Yang H. et al, (2024), Sci Adv, 10
Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations.
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Argentieri MA. et al, (2024), Nat Med
Expanding the scope of a catalogue search to bioisosteric fragment merges using a graph database approach
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Wills S. et al, (2024)
Amino acid and viral binding by the high-affinity Cationic Amino acid Transporter 1 (CAT1) from Mus musculus
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Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity.
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Singh S. et al, (2024)
Paralogue-Selective Degradation of the Lysine Acetyltransferase EP300
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