Controlling the activation of the NLRP3 inflammasome by post-translational modifications (PTMs) of critical protein subunits has emerged as a key determinant in inflammatory processes as well as in pathophysiology. In this review, we put into context the kinases, ubiquitin processing and other PTM enzymes that modify NLRP3, ASC/PYCARD and caspase-1, leading to inflammasome regulation, activation and signal termination. Potential target therapeutic entry points for a number of inflammatory diseases focussed on PTM enzyme readers, writers and erasers, leading to the regulation of inflammasome function, are discussed. Video Abstract.
Journal article
2021-02-24T00:00:00+00:00
19
Drug targets, NLRP3 inflammasome, Post-translational modifications, Protein interaction, Signalling, Animals, Humans, Inflammasomes, NLR Family, Pyrin Domain-Containing 3 Protein, Protein Processing, Post-Translational