Atorvastatin (Lipitor) by MCR
Zarganes-Tzitzikas T., Neochoritis CG., Dömling A.
A concise and convergent synthesis of the atorvastatin, the best-selling cardiovascular drug of all time, is presented. Our approach is based on an Ugi reaction, which shortens the current synthetic route and is advantageous over the published syntheses.