Tryfon Zarganis-Tzitzikas
Team Leader - Medicinal Chemistry
Tryfon obtained his B.Sc. in Chemistry from the Aristotle University of Thessaloniki, Greece in 2010 and his M.Sc., summa cum laude, in Synthetic Organic Chemistry in 2012, under the guidance of Prof. J. Stephanidou – Stephanatou at the same University. In 2017 he obtained his Ph.D., cum laude, in Medicinal Chemistry under the guidance of Prof. Alexander Dömling in the Group of Drug Design at the University of Groningen, The Netherlands. His thesis focused on ‘’Innovative Multicomponent Reactions and their Use in Medicinal Chemistry”.
After obtaining his Ph.D., Tryfon joined Syncom B.V. as a medicinal chemist working on an immuno-oncology project in close collaboration with the University of Groningen. Since 2014, he has been a co-founder and CSO of TelesisPharma B.V. in Groningen, a company focusing on exploring novel synthetic routes to APIs using multicomponent reactions. In Dec 2018, he joined Prof. Paul Brennan’s group at the Oxford Drug Discovery Institute at the University of Oxford, UK, as a postdoctoral scientist focusing on Dementia, a project funded by Alzheimer’s Research, UK.
Recent publications
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Covalent Inhibitors of S100A4 Block the Formation of a Pro-Metastasis Non-Muscle Myosin 2A Complex.
Journal article
Giroud C. et al, (2024), J Med Chem, 67, 18943 - 18956
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Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors.
Journal article
Ważyńska MA. et al, (2023), J Med Chem, 66, 9577 - 9591
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Erratum: Amenamevir by Ugi-4CR (Green Chem. (2023) 25 (1322–1325) DOI: 10.1039/D2GC04869H)
Journal article
Li X. et al, (2023), Green Chemistry, 25
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Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors.
Journal article
Schuller M. et al, (2023), Pathogens, 12
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Amenamevir by Ugi-4CR
Journal article
Li X. et al, (2023), Green Chemistry
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Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane.
Journal article
Frank N. et al, (2022), Nature, 611, 721 - 726
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Local Anesthetics via Multicomponent Reactions.
Journal article
Thomaidi M. et al, (2022), ChemMedChem, 17
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Supported Gold Nanoparticle-Catalyzed Selective Reduction of Multifunctional, Aromatic Nitro Precursors into Amines and Synthesis of 3,4-Dihydroquinoxalin-2-Ones.
Journal article
Iordanidou D. et al, (2022), Molecules, 27
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Biphenyl Ether Analogs Containing Pomalidomide as Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction
Journal article
Shaabani S. et al, (2022), Molecules, 27
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Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane
Preprint
Frank N. et al, (2022)