Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain

Congratulations to DPhil student Aleksandra Szykowska on her new publication in the journal Structure describing the binding modes and functional activity of scFv antibody fragments that bind to the extracellular Ig-like domain of TREM2, a receptor expressed by microglia associated with an increased risk of Alzheimer's disease. We hope that the detailed characterization of their epitopes and properties will facilitate the use of these renewable binders as structural and functional biology tools for TREM2 research.