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Protein Crystallography (PX)

The laboratory that brought you the Crystal shifter and co-developed the XChem fragment screening platform at Diamond Light Source.

The focus of our research is the establishment of methods to ensure that X-ray structures can serve as a routine and predictive tool for generating novel chemistry for targeting proteins. This focus area includes both early development of leading-edge technologies and approaches, and crucially deployment into definable platforms

PX and XChem combined group meeting at Linacre during May 2024

Research areas

 

Lattice engineering 

  • Crysalins 

  • Particle display 

  • Rapid binders 

  • Fast C2C (constructs-to-crystals) 

Anti-infectives 

  • Fungal: AfOX (SA) 

  • AMR (advanced discussions) 

Exploratory 

  • Cryo-EM; proteomics: GNC2 

  • Plants FFF (fast forward fragments): FatA 

  • Degraders: Paedeatric cancers, PROTECT 

Algorithms 

  • SABS and OPIG 

 

The crystal shifter in action!

Our team

Selected publications