Joseph Newman
Group leader – Structural biology of DNA repair
I studied my undergraduate degree in biochemistry in the University of Edinburgh UK from 1998-2002. I did a PhD in structural biology in the lab of Prof David Rice at the University of Sheffield UK from 2003-2007. From 2007-2013 I joined the lab of Prof Rick Lewis at Newcastle University UK where I studied the structure and biophysics of protein complexes involved in central carbon metabolism and biofilm formation in Bacillus subtilis. From 2013 I have been a post-doctoral researcher at the University of Oxford, initially in the Structural Genomics Consortium and now the Centre for Medicines discovery.
My current research interests are the structure and function of DNA repair enzymes including helicases and nucleases. I use structural biology to identify and develop novel starting points for small molecule inhibitors with utility in human health as either cancer therapeutics or antiviral agents.
Recent publications
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Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity.
Journal article
Syed A. et al, (2023), Nucleic Acids Res
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Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development.
Journal article
Imprachim N. et al, (2022), Nucleic Acids Res
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Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts
Preprint
Ye M. et al, (2022)
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Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development
Preprint
Imprachim N. et al, (2022)
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FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency.
Journal article
Rota IA. et al, (2021), Sci Adv, 7