The Intersection of Structural and Chemical Biology - An Essential Synergy.
Zuercher WJ., Elkins JM., Knapp S.
The continual improvement in our ability to generate high resolution structural models of biological molecules has stimulated and supported innovative chemical biology projects that target increasingly challenging ligand interaction sites. In this review we outline some of the recent developments in chemical biology and rational ligand design and show selected examples that illustrate the synergy between these research areas.